Detecting Clusters of Mutations
Figure 1
Q-landscape of the E. coli gene frdA (fumarate reductase flavoprotein subunit).
Q has four local minima. Thus we have four potential clusters, starting at mutation numbers 4, 7, 10, and 23. The horizontal lines show the range of each potential cluster. The second cluster (dotted line) overlaps with the third cluster, which has lower Q. Therefore, we exclude the second cluster and obtain three potential mutation clusters (dashed lines). After correction for multiple testing, only one significant cluster remains, the one starting at position 10.