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In Vitro Identification and Characterization of CD133pos Cancer Stem-Like Cells in Anaplastic Thyroid Carcinoma Cell Lines

Figure 5

Sensitivity of ARO/CD133pos and ARO/CD133neg cells to chemotherapy agents.

(A) MTT analysis after 48 hours of culture in the presence of 0.5, 1, 1.5 and 2 µM doxorubicin (B) after 48 hours in the presence of 5, 10, 15 and 20 µM cisplatin (C) after 48 hours in the presence of 10, 30 and 100 µM etoposide. Data are expressed as mean values±SD and are representative of three independent experiments (p≤0.05). (D) (E) (F) represent BrdU analysis in the same conditions of A, B, C (p≤0.001). Dotted line represents ARO/CD133neg cells and continuous line represents ARO/CD133pos cells in all graphs.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0003544.g005