Dynamical Systems Analysis of Mitochondrial BAK Activation Kinetics Predicts Resistance to BH3 Domains
Figure 7
Unified model incorporating both b1 driven and spontaneous activation of B.
A) Reaction scheme showing the interaction between A1max, A2max, b21, b22, B in the presence of b1. In this reaction, A1 and A2 bind to b1, B and B* and are at maximum concentration of 10 nM. B bifurcates in its activation with equal probability leading to either spontaneous activation or b1 driven activation. B) The corresponding system of differential equations associated with this unified reaction scheme. C) Graph of the iterated solutions of the corresponding system of equations, showing log b1 ratio versus B* for b21 alone or b21 plus b22.