Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition
Figure 6
Reduced level of IL-4 secretion from PS1/PS2 and not RBP-J deficient Th2 cells.
(A, B) PS1/PS2-deficient T cells have significant reduction in IL-4 cytokine production when compared to RBP-J-deficient T cells independent of the mode of re-stimulation. The experiments were conducted as described in Figures 5. Data is presented as the relative level of IL-4, determined by comparing the IL-4 secretion from individual mouse over the maximum level attained in each separate experiment. The P value was determined by two-tailed paired t test.