Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse
Figure 6
Mutant frequencies in intestinal subparts.
(A) Spontaneous lacZ mutant frequencies in the mucosal or serosal layers of the duodenum, jejunum or ileum of 19-month old mice. Significant differences were observed between the inner (mucosa) layer and the outer (serosa) layer in both the duodenum (*; p = 0.0047) and the jejunum (**; p = 0.0003) regions of the small intestine. (B) Total lacZ mutant frequencies in the serosal layer of the duodenum of 3-month and 19-month old mice (p<0.0001).