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Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse

Figure 6

Mutant frequencies in intestinal subparts.

(A) Spontaneous lacZ mutant frequencies in the mucosal or serosal layers of the duodenum, jejunum or ileum of 19-month old mice. Significant differences were observed between the inner (mucosa) layer and the outer (serosa) layer in both the duodenum (*; p = 0.0047) and the jejunum (**; p = 0.0003) regions of the small intestine. (B) Total lacZ mutant frequencies in the serosal layer of the duodenum of 3-month and 19-month old mice (p<0.0001).

Figure 6

doi: https://doi.org/10.1371/journal.pone.0000876.g006