Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms
Fig 2
Enriched gene interaction network detected with opposite expression patterns in PZQ-treated paired or unpaired mature females.
This gene interaction network is significantly enriched (p-value = 10−52) with differentially expressed genes related to cellular development and drug metabolism whose expression was affected by PZQ in paired as well as in unpaired mature females (with opposite patterns). The shapes of elements correspond to different types of molecules, as indicated in the inset box. Arrows indicate the relationship between the elements: dashed or solid lines indicate indirect or direct interactions, respectively. The color intensity is proportional to the expression value, computed as log2 [PZQ/Control]; red corresponds to positive log-ratios, i.e. these genes were up-regulated in paired females treated with PZQ when compared with the no-drug controls; grey corresponds to a gene present in the analysis but not differentially expressed. In humans, a number of gene homologs in this network encode proteins that are known drug targets and the corresponding drugs (Rx) are indicated.