Comparative Pathogenesis of Alkhumra Hemorrhagic Fever and Kyasanur Forest Disease Viruses in a Mouse Model
Figure 5
Immunohistochemical findings in BALB/c mice experimentally infected with KFDV P9605 and AHFV Zaki-1.
(A and B) Immunohistochemistry of the brain. (A) Mock. (B) Foci of positive immunostaining for KFDV P9605 (brown) within neurons and some astrocytes at day 8 post-infection. (C and D) Immunohistochemistry of the kidney at day 4 post-infection. (C) Mock. (D) AHFV Zaki-1-infected mouse, viral antigen (brown) can be found scattered in the cortex and the medulla. Positive immunostaining for AHFV Zaki-1 in mesangial cells of the glomeruli (inset). (E and F) Immunohistochemistry of the liver on day 6 post-infection. (E) Mock. (F) AHFV Zaki-1-infected mouse. AHFV Zaki-1 immunostaining (brown) in sinusoids and Kupffer cells (inset).