Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans
Figure 2
Cytotoxicity of mycolactone variants with modifications in the upper side chain.
Cells were treated for 48 hours with different concentrations of PG-157, PG-165 or PG-182 and stained with annexin-V-FITC and PI. Flow cytometry was used to determine the annexin-positive (A+) and PI-positive (PI+) cell populations. Triplicate samples were analyzed and mean values as well as standard deviations are shown.