Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor
Figure 3
Effect of BZL on P-gp activity.
Accumulation of Rh123, in the presence or absence of verapamil (VER; 100 µM), was inversely correlated with P-gp activity in cells pretreated with BZL (200 µM) or vehicle (C) for 48 h. Data are presented as percentages referred to the accumulation in C, considered as 100%, and were expressed as means ± S.D. (n = 3). a: significantly different from C; b: significantly different from C+VER; c: significantly different from BZL. Significance levels were set at p<0.05.