Complement Inhibitors from Scabies Mites Promote Streptococcal Growth – A Novel Mechanism in Infected Epidermis?
Figure 3
Scabies mite complement inhibitors enhance group A streptococcal growth in human whole blood.
(a) Increased GAS growth in whole blood from a human donor with a type-specific immune response to the GAS strain investigated (D1) in presence of SMSB4 [25 µg/ml], SMSB3, SMIPP-S I1 or BSA [200 µg/ml]. Shown are means ± SEM (n = 4 experiments). (b) Means ± SEM of n = 6 to 12 standardized assays with whole blood from two donors who did not exhibit type-specific immunity to the GAS strain used in this study. (D2, D3) supplemented with heat-inactivated antibody serum from D1. (c) Novel model on potential scabies, bacteria and host interactions. **p<0.01, ***p<0.001 by t test (GraphPad Prism). S. pyogenes strain 2967emm1 was isolated from human skin.