Diverse Effects on Mitochondrial and Nuclear Functions Elicited by Drugs and Genetic Knockdowns in Bloodstream Stage Trypanosoma brucei
Figure 5
Representative growth curves for RNAi cell lines targeting TOPIBL, NOPP44/46, or TOPIImt.
Tet was added at day 0 to initiate destruction of the targeted RNA. The RNAi-induced cells from the final day of the growth curve were used in the experiments shown in Figure 6. The percent of dead cells at that point is listed. NOPP44/46 protein levels were reduced 44% as shown by immunoblotting (unpublished results).