Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs
Figure 4
M. ulcerans–produced mycolactone diffuses in internal organs of experimentally infected mice.
The distribution of mycolactone is shown in internal organs of mice ten weeks post sc infection with 104 M. ulcerans bacilli. The amount of mycolactone was determined by ESI-LC-MS analysis of acetone-soluble lipid extracts prepared from pools of 5 homogenized organs. Data correspond to the calculated amount of total mycolactones (A/B and C forms) per organ, nd: not detected.