HIV-1 Transmission during Early Infection in Men Who Have Sex with Men: A Phylodynamic Analysis
Figure 3
HIV diagnoses and CD4 cell count through time.
(A) The sample proportion (points) and estimated proportion (lines) of diagnoses that are concurrent with AIDS diagnosis over time, and the estimated proportion of diagnoses that are not concurrent with AIDS. The diameter of points is proportional to the number of diagnoses used to calculate the proportions. (B) The sample mean (points) and estimated mean (lines) CD4 cell count in newly diagnosed individuals over time. The mean is calculated from CD4 counts aggregated by year. The diameter of points is proportional to the number of CD4 counts used to calculate the mean. Inset: The mean CD4 cell count by stage of infection, which gives the best fit (least squares) to the observed trend in mean CD4 count over time.