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Development of a Standardized Screening Rule for Tuberculosis in People Living with HIV in Resource-Constrained Settings: Individual Participant Data Meta-analysis of Observational Studies

Figure 4

Algorithm for TB screening in person living with HIV in HIV prevalent and resource-constrained settings.

* Every person living with HIV needs to be evaluated for ART eligibility, and all settings providing care should reduce TB transmission through proper measures. ** Chest radiography is not required to classify patients into the TB and not-TB groups, but can be done, if available, to increase the sensitivity of screening. *** Assess for contraindications, including active hepatitis (acute or chronic), regular and heavy alcohol consumption, and symptoms of peripheral neuropathy, is required prior to initiating IPT. Past history of TB is not a contraindication for starting IPT. Tuberculin skin test may be performed as part of eligibility screening in some settings. **** Investigations for TB should be done in accordance with existing national guidelines.

Figure 4

doi: https://doi.org/10.1371/journal.pmed.1000391.g004