Prophylactic and Therapeutic Efficacy of Human Monoclonal Antibodies against H5N1 Influenza
Figure 2
Pulmonary Virus Titers and Extrapulmonary Dissemination of A/Vienam/1203/04 (H5N1) Following Passive Immunization
The data depict the mean (± interquartile range) viral titer in (A) lungs, (B) brain, and (C) spleen of groups of five BALB/c mice passively immunized by i.p. injection of mAbs FLA3.14, FLA5.10, or the control mAb D2.2, then challenged i.n. with 50 μl of A/Vietnam/1203/04 (105 TCID50/mouse) 24 h later. On days 2 and 4 there was significantly less virus recovered in splenic and pulmonary tissue of mice that had received either FLA3.14 or FLA5.10 than mice that had received the control mAb, D2.2. (* p < 0.01 versus D2.2; ** p < 0.001 versus D2.2). The lower limit of detection (1.5 log10 TCID50/g) is shown by the arrow.