The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets
Fig 5
Nfatc1 differentially regulates cell cycle genes in mouse and human islets.
The regulation of expression for selected cell cycle genes is illustrated in mouse (A) and human (B) islets following overexpression of either ca-Nfatc1 or ca-Nfatc2. The data is plotted as the log2 fold-change in expression relative to that measured in Ad-GFP (negative control) treated islets. Mouse expression values were obtained from whole-islet RNA-sequencing; human expression values were determined by qPCR. *, P < 0.05 relative to negative control. N = 5 for mouse islets; N ≥ 3 for human islets.