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APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans

Fig 3

APLP2 genotype and reading behaviour interact to influence refractive eye development in children.

Refractive development in ALSPAC participants (n = 5,200) was modelled over the 8–15 year age range. Models included as a predictor variable either rs188663068 genotype (A, C, D) or a binary term categorizing children as spending a “high” or “low” amount of time reading at age 8½ years (B). Analyses used the full sample (A), those with information available on time spent reading (B), or a stratified sample consisting of the low (C) or high (D) readers.

Fig 3

doi: https://doi.org/10.1371/journal.pgen.1005432.g003