Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold
Fig 5
Metabolic phenotype of male nPE mutant mice.
(A) Body weight. n = 5–11. (B) Body composition measured by NMR of mice age 16 wk. n = 15. (C) Liver mass measured in mice aged 16 wk. n = 6. (D) Food intake and (E) metabolic efficiency measured for 1 wk (age 6–7 wk). n = 5–9. (F) Body weight data from (A) plotted against Pomc mRNA data from Fig. 3C. All quantitative data are presented as mean ± 1 S.E.M. Genotype means were compared by two-tailed t-tests. * P < 0.05, *** P < 0.001 compared to +/+.