Recombination in the Human Pseudoautosomal Region PAR1
Figure 4
Separate LD-based recombination rates in PAR1 in three human continental groups, around the binding sites of the PRDM9 B allele.
The B and other alleles predicted to bind similar motifs predominate in Europe and East Asia (91% frequency), but not in Africa (58% frequency). In PAR1, the recombination pattern is consistent with being activated by PRDM9, as both Asian and European populations show a much stronger increase in rate at these binding sites than Africans (P = 0.002 African/Asian, P = 0.02 African/European).