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Genome-Wide DNA Methylation Analysis Predicts an Epigenetic Switch for GATA Factor Expression in Endometriosis

Figure 2

The global CpG methylation pattern in healthy and endometriotic stroma.

The methylation in EIUM (n = 6) and OSIS (n = 6) with (+) or without (−) IVD was examined by (A) principal component analysis and (B) hierarchical clustering based upon on the 470,540 probes from the methylation array (letters B, G, H, I, L, and M denote EIUM; O, P, Q, R, U, and X, denote OSIS). The normalized density estimation was determined (C) from the β-values of all 12 untreated samples. Scatter plots compare the β-values for individual CpGs between (D) EIUM- and OSIS-, (E) EIUM+ and EIUM-, and (F) OSIS+ and OSIS−. Data plotted in red differed in average β-value by at least 0.15. Numbers in the upper left and lower right corners of each plot show the total number of hyper- and hypomethylated CpGs, respectively.

Figure 2

doi: https://doi.org/10.1371/journal.pgen.1004158.g002