Zinc Finger Transcription Factors Displaced SREBP Proteins as the Major Sterol Regulators during Saccharomycotina Evolution
Figure 6
YlUPC2 and YlSRE1 regulate expression of ergosterol genes during hypoxic adaptation.
Expression of the indicated ERG pathway genes was tested using qRT-PCR. All strains were grown to an A600 of 1.0 in SC media at 28°C under normoxic conditions (21% O2) and then switched to an hypoxic environment (1% O2) for 2 hours. Expression was normalized against actin, and is shown relative to the wild type strain grown in normoxia. Standard error of three replicates is shown. ** P<0.05, *** P<0.005.