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Ablating Adult Neurogenesis in the Rat Has No Effect on Spatial Processing: Evidence from a Novel Pharmacogenetic Model

Figure 3

Ablating adult neurogenesis decreases anxiety.

A Time to begin eating a novel food in a novel environment, expressed as the mean latency (± s.e.m). B Time to begin eating as a survival plot (black line = wild type, n = 18, Red line = GFAP-TK, n = 22). C Time to emerge from a black alley and enter a white alley expressed as the mean latency (± s.e.m). D Time to emerge from a black alley survival plot (black line = wild type, n = 18, Red line = GFAP-TK, n = 22). Grey vertical line at right side of survival plots represents the termination of the experiment. *p<0.05, **p<0.01 significantly different from GCV-treated wild type controls. E Time to begin eating a novel food and F Time to emerge from a black alley in untreated WT (n = 26) and GFAP-TK (n = 18) rats.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1003718.g003