Joint Molecule Resolution Requires the Redundant Activities of MUS-81 and XPF-1 during Caenorhabditis elegans Meiosis
Figure 1
MUS-81 and HIM-6 prevent the accumulation of recombination intermediates and chromosome instability.
(A) Distribution of RAD-51 foci in WT, mus-81, him-6, and mus-81; him-6 animals. Zone definitions: 1 Early mitotic 2 Late mitotic 3 Transition 4 Early pachytene 5 Mid pachytene 6 Late pachytene 7 Diplotene. (B) Mean number of RAD-51 foci per nucleus from A. (C) Average number of DAPI-stained bodies in diakinesis oocytes of WT, mus-81, him-6, and mus-81; him-6 animals. (D) Representative images of DAPI-stained bodies in diakinesis oocytes of WT, mus-81, him-6, and mus-81; him-6 animals. Bars 2 µm.