BMS1 Is Mutated in Aplasia Cutis Congenita
Figure 6
Comparative proteomics and global gene expression profiling reveals a central role of p21 activation in ACC.
a. The two top-ranked networks were merged to generate a combined network of the differentially present proteins in ACC fibroblasts (center). Differentially expressed genes identified in the transcript profiling microarray experiments are indicated in the periphery of the proteomic network, and interactions are illustrated by arrows. This analysis revealed the highest number of interactions to include p21 (CDKN1A) and hnRNPA2B1. b. Interaction analysis among p21 (CDKN1A) and the entire merged proteomic network revealed a central role of p21, showing that p21 activation is a central determinant of the ACC phenotype.