HDAC7 Is a Repressor of Myeloid Genes Whose Downregulation Is Required for Transdifferentiation of Pre-B Cells into Macrophages
Figure 2
HDAC7 re-expression interferes with the gene transcriptional program of the converted macrophages.
Heat-maps showing significantly (corrected p-value <0.05) enriched GO Biological Process (A), Cellular Components (B) and Molecular Functions (C) categories among the up-regulated genes affected by the re-expression of HDAC7 during transdifferentiation of pre-B cells into macrophages. Colours toward red indicate high statistic significance, yellow indicates low statistic significance, and gray indicates no statistical significance. The list of genes for the enrichment analysis in each column is as follows: C10-MSCV-48h includes genes up-regulated after β-estradiol treatment for 48 hours. C10-HDAC7-48h includes genes up-regulated after β-estradiol treatment for 48 hours which are down-regulated in the presence of HDAC7 (HDAC7 re-expression). C10-MSCV-72h includes genes up-regulated after β-estradiol treatment for 72 hours. C10-HDAC7-72h includes genes up-regulated after β-estradiol treatment for 72 hours which are down-regulated after re-expression of HDAC7.