Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
Figure 3
Variability in genetic risk for type 2 diabetes.
Individuals are represented by vertical multicolored rectangles. Individual bars in each rectangle represent one of the 16 SNPs associated with type 2 diabetes. Bar colors indicate the following: red: homozygosity for a risk allele; blue∶heterozygosity; green∶homozygosity for a protective allele; white: missing genotype. The order of the SNPs is preserved across individuals. The x-axis shows genetic risk and the y-axis shows each population. The purple line is a locally weighted linear regression curve displaying the general direction of disease susceptibility as populations migrated from West to East. Genetic risk is lower in East Asians.