Genetic Architecture of Skin and Eye Color in an African-European Admixed Population
Figure 5
Power and candidate gene analyses.
(a) Power estimated at three different alpha levels, plotted as a function of effect size (number of MM units by which each copy of the derived allele lightens skin pigmentation). The results shown here are based on derived allele frequencies of 0.1 and 0.9 in the ancestral African and European populations, respectively. The effect sizes detected in Cape Verde for the four major skin color loci are shown in blue; effect sizes for ASIP and KITLG as estimated (see Material and Methods) from [12] and [15], respectively are shown in red. (b) Distribution of P values for SNPs in 47 candidate genes, 16 regions with strong signatures of selection, and random SNPs, all shown as a q-q plot of the −log10 (P) values. Observed −log10 (P) values specifically for ASIP and KITLG SNPs are shown above the plot.