Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid
Figure 9
Model to explain how the state of acetylation/deacetylation of H3K56 influences SCR.
Newly incorporated Histone H3 in the newly born sister-chromatids are acetylated, whereas the unreplicated DNA contains deacetylated histone H3. In the absence of K56 acetylation or when all histones H3 are acetylated, the recombination apparatus does not efficiently recognize the sister and the SCR preference is lost.