A Hybrid Likelihood Model for Sequence-Based Disease Association Studies
Figure 4
BOMP Power estimates for multiple genes (24) case-control studies.
Power estimates for BOMP; each estimate is based on 250 simulated case-control studies ((approximately one-third each from disease etiologies Rare, LowFreq and KeyRegion). The genomic individuals each had 24 genes, the ratio of genes with causal variants to those without causal variants was either 1∶3 (6 causal, 18 non-causal), 1∶1 (12 causal, 12 non-causal), or 3∶1 (18 causal, 6 non-causal). AA = African-American simple bottleneck demographic model. EA = European-American exponential growth demographic model.