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Vsx2 Controls Eye Organogenesis and Retinal Progenitor Identity Via Homeodomain and Non-Homeodomain Residues Required for High Affinity DNA Binding

Figure 11

Models of Mitf regulation in RPCs during normal retinal development.

(A) In response to RPC program activators, Vsx2 expression is initiated and newly produced protein interacts with preexisting MITF protein, preventing access to targets required for the pigmentation program. (B) Once VSX2 protein expression is established, it regulates Mitf activity by directly repressing Mitf transcription of isoforms such as D-Mitf and binds to MITF proteins produced from promoters that Vsx2 does not efficiently repress such as A-Mitf and possibly H-Mitf.

Figure 11

doi: https://doi.org/10.1371/journal.pgen.1002924.g011