Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1
Figure 4
Loss of mir-181ab1 inhibits leukemia development induced by the human NOTCH1 mutant P12ΔP.
(A) Kaplan-Meier survival curve showing the effects of loss of mir-181ab1 on the percentages of mice surviving at different time points after T-ALL induction with P12ΔP (p<0.01, n = 20 mice/experimental group, a representative plot of two independent experiments is shown). (B) Effects of loss of mir-181ab1 on the percentage of total P12ΔP-infected cells (all GFP+ cells) and the percent of P12ΔP-infected DP cells (GFP+ DP cells) in peripheral blood at different time points after reconstitution (*, p<0.05). (C and D) The percentage of GFP+ cells (upper panel) and GFP+ DP cells (lower panel) in BM, spleen and thymus of T-ALL mice at (C) 6 to 7 weeks or (D) ∼48 weeks after transplantation (*, p<0.05).