Evidence of Inbreeding Depression on Human Height
Figure 1
Three alternative measures of mean homozygosity, with 95% confidence intervals, by population sample.
(A) shows mean FROH by population sample. FROH is defined as the percentage of the genotyped autosomal genome in ROH measuring at least 1.5 Mb. Mean values of FROH per population (with 95% confidence intervals) are: CROATIA-Korčula = 1.27 (1.18, 1.36); CROATIA-Split = 0.65 (0.59, 0.71); CROATIA-Vis = 0.94 (0.87,1.01); EGCUT = 0.56 (0.54, 0.58); ERF = 1.12 (1.04, 1.20); FINRISK = 0.79 (0.77, 0.82); HBCS = 0.63 (0.60, 0.65); H2000 = 0.84 (0.82, 0.86); INGI-CARL = 0.78 (0.65, 0.91); INGI-FVG = 1.49 (1.40, 1.58); INGI-VB = 0.76 (0.71, 0.81); LBC1921 = 0.30 (0.25, 0.35); LBC1936 = 0.26 (0.24, 0.28); MICROS = 0.93 (0.87, 0.99); NFBC1966 = 1.02 (1.00, 1.04); NSPHS = 2.83 (2.64, 3.02); ORCADES = 0.81 (0.75, 0.87); QIMR = 0.22 (0.21, 0.23); RS = 0.29 (0.28, 0.30); SOCCS = 0.30 (0.28, 0.32); YFS = 0.81 (0.79, 0.83). (B) shows mean FROHLD by population sample. FROHLD is defined as the percentage of the genotyped autosomal genome in ROH measuring at least 1.0 Mb, derived from a panel of independent SNPs. Mean values of FROHLD per population (with 95% confidence intervals) are: CROATIA-Korčula = 0.67 (0.61, 0.73); CROATIA-Split = 0.13 (0.11, 0.15); CROATIA-Vis = 0.48 (0.43, 0.53); EGCUT = 0.10 (0.09, 0.10); ERF = 0.53 (0.48, 0.58); FINRISK = 0.21 (0.20, 0.23); HBCS = 0.13 (0.11, 0.14); H2000 = 0.23 (0.22, 0.24); INGI-CARL = 0.44 (0.34, 0.54); INGI-FVG = 0.93 (0.86, 0.99); INGI-VB = 0.41 (037, 0.45); LBC1921 = 0.05 (0.02, 0.09); LBC1936 = 0.02 (0.01, 0.03); MICROS = 0.47 (0.43, 0.51); NFBC1966 = 0.32 (0.31, 0.33); NSPHS = 1.17 (1.07, 1.27); ORCADES = 0.35 (0.31, 0.39); QIMR = 0.013 (0.011, 0.015); RS = 0.04 (0.01, 0.07); SOCCS = 0.03 (0.02, 0.04); YFS = 0.20 (0.19, 0.21). (C) shows mean Fhom by population sample. Fhom is defined as the percentage of genotyped autosomal SNPs that are homozygous. Mean values of Fhom per population (with 95% confidence intervals) are: CROATIA-Korčula = 65.47 (65.43, 65.51); CROATIA-Split = 65.28 (65.25, 65.31); CROATIA-Vis = 65.61 (65.58, 65.64); EGCUT = 65.69 (65.68, 65.70); ERF = 65.32 (65.29, 65.35); FINRISK = 65.25 (65.23, 65.27); HBCS = 65.13 (65.12, 65.14); H2000 = 65.24 (65.23, 65.25); INGI-CARL = 65.20 (65.14, 65.26); INGI-FVG = 65.53 (65.49, 65.57); INGI-VB = 65.18 (65.16, 65.20); LBC1921 = 65.00 (64.97, 65.03); LBC1936 = 65.00 (64.99, 65.01); MICROS = 65.26 (65.23, 65.29); NFBC1966 = 65.27 (65.26, 65.28); NSPHS = 66.09 (66.01, 66.17); ORCADES = 65.37 (65.34, 65.40); QIMR = 64.75 (64.74, 64.76); RS = 65.00 (64.99, 65.01); SOCCS = 64.97 (64.95, 64.99); YFS = 65.26 (65.25, 65.27).