Transcriptional Control in Cardiac Progenitors: Tbx1 Interacts with the BAF Chromatin Remodeling Complex and Regulates Wnt5a
Figure 4
Tbx1−/−;Wnt5a−/− embryos have severe hypoplasia of SHF–derived heart.
(A–D′) Right view (A–D) and frontal view (A′–D′) of Tbx1−/−; Wnt5a−/− embryos hybridized in situ with a cyclin D2 probe showed severe hypoplasia of the OFT and the RV at E9.5, compared with littermate controls. (A″–D″) Sagittal sections from whole-mount embryos hybridized with the cyclin D2 probe confirmed the severe cardiac defect in Tbx1−/−; Wnt5a−/− embryos. (A′″–D′″) high magnification of the regions identified with a square in panels A″–D″. Scale bars: 100 µm.