Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells
Figure 1
Tcof1 heterozygous mutant mice show small brain.
(A) Dorsal view of wild-type (+/+) and Tcof1 heterozygous mutant (+/−) brains of P14 mice. (B) Brain weight per body weight and body weight of wild-type (n = 6) and Tcof1+/− mice (n = 6). (C) Coronal sections of wild-type (+/+) and Tcof1 heterozygous (+/−) cerebrum stained with HE. The brain is much smaller, but tissue architecture and morphology is normal. Scale Bars: C, 200 µm.