The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
Figure 2
Two thirds of candidate genes for T1D are expressed in pancreatic beta cells.
(A) T1D candidate genes ranked by the odds ratio for their risk allele (http://t1dbase.org). Based on our present data, 25 candidate genes out of 41 (61%) were expressed in human beta cells (marked with *). (B) INS-1E cells were left untreated or treated with IL-1β+IFN-γ for the indicated times. The expression of the T1D candidate gene SH2B3 was assayed by qRT-PCR and normalized to the housekeeping gene GAPDH. The results are means ± SEM of 3–6 independent experiments. *p<0.05 versus untreated cells.