Transcription Is Required to Establish Maternal Imprinting at the Prader-Willi Syndrome and Angelman Syndrome Locus
Figure 1
The PWS/AS imprinted domain and corresponding regions covered by the BAC transgenes.
(A) Schematic diagram of the murine PWS/AS locus. Genes expressed from the paternal allele are shown above the locus (blue rectangles) and maternally expressed gene are shown below (red rectangles)(not to scale). (B) Schematic diagram of the Snrpn locus and sequences included in the 380J10 and 425D18 BACs. The nine identified Snrpn U exons (filled red boxes) are shown as well as five additional exons, termed α-ε (open boxes) [17]. For each BAC, the extent of genomic sequence relative to Snrpn is indicated (not to scale).