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Roles of the Espin Actin-Bundling Proteins in the Morphogenesis and Stabilization of Hair Cell Stereocilia Revealed in CBA/CaJ Congenic Jerker Mice

Figure 9

Stereociliary width measurements for cochlear hair cells in early postnatal +/+, +/je, and je/je mice.

Width measurements for 150 (P0) or 100 (P5) stereocilia on hair cells of the designated type (outer or inner), cochlear location and genotype are plotted as mean ± SD (*, p<0.001). (A,B) Stereocilia on outer (A) and inner (B) hair cells in je/je mice are significantly thinner than those in +/+ mice in all cochlear regions at P0 and P5, while those in +/je mice are intermediate in width and significantly different from those in +/+ and je/je mice at P0, except on inner hair cells in the apical region. The stereocilia of outer and inner hair cells in all three genotypes and cochlear regions show significant increases in width between P0 and P5 (p<0.001).

Figure 9

doi: https://doi.org/10.1371/journal.pgen.1002032.g009