Transcription Initiation Patterns Indicate Divergent Strategies for Gene Regulation at the Chromatin Level
Figure 1
Promoter Classes Reflect Distinct Profiles of Nucleosome Organization.
Profiles are based on promoters classified as Narrow Peak (NP), Broad with Peak (BP), and Weak Peak (WP), and show the region of –1 kb to +1 kb around the designated TSS. RI refers to average levels at random intergenic sites, which is used as a baseline. (A) Increased H2A.Z levels (p<10E-36), (B) increased bulk levels, and consistent spacing were observed for human BP and WP promoters compared to NP. DNase hypersensitive sites revealed a more accessible nucleosome-free region at BP and WP but not at NP promoters (C), yet pol II levels were higher at NP promoters (D).