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Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles

Figure 2

Candidate MEs, but not control genes, show systemic interindividual variation in DNA methylation.

(A–E) Scatter plots illustrating inter-tissue correlation of interindividual differences in DNA methylation at candidate MEs BOLA3, FLJ20433, PAX8, SLITRK1, and ZFYVE28. The top of each panel indicates the genomic region. Vertical lines represent CpG sites, and gray horizontal bars represent CpG islands. The CpG sites covered by each pyrosequencing assay are indicated by an asterisk. All 5 candidate MEs show significant inter-tissue correlation, indicating systemic interindividual variation in DNA methylation. (F–H) Control genes IGF2, GNASAS, and IL10 exhibit interindividual variation in DNA methylation comparable to that of the candidate MEs, but there is no significant inter-tissue correlation. (Correlation coefficients and P values for all regions are provided in Table S3.)

Figure 2

doi: https://doi.org/10.1371/journal.pgen.1001252.g002