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Epigenetic Regulation of a Murine Retrotransposon by a Dual Histone Modification Mark

Figure 3

Effect of TSA and Aza-dC treatment on the expression of transposable elements.

(A) Logarithmically growing fibroblasts show increased mRNA expression levels of VL30 LTR elements when treated with TSA. Expression levels were determined with qRT-PCR. Values are normalised to HPRT expression and are shown relative to the expression in untreated HDAC1+/+ fibroblasts. Treatment as in Figure 2. N = 3; ± SD *p<0.05. (B) Aza-dC causes high level induction of VL30 and IAP LTR element expression. N = 3; ± SD *p<0.05.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1000927.g003