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Interpretation of Genetic Association Studies: Markers with Replicated Highly Significant Odds Ratios May Be Poor Classifiers

Figure 1

Accuracy curves for binary markers.

The curves of accuracy points (FPF, TPF pair) for binary markers with ORs 1.5, 10, and 50 are plotted. The black diamonds and horizontal dotted line highlight the points (FPF, TPF) = (FPF, 80%) on the accuracy curves. The ORs are marked on the curves.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1000337.g001