Skip to main content
Advertisement

< Back to Article

Divergent Evolution of Human p53 Binding Sites: Cell Cycle Versus Apoptosis

Figure 2

Distribution of Human-to-Mammal TFBS Conservation Scores

Graphed for each (human-to-mouse, -rabbit, -rat, and -dog) comparison in (A–D) are: the percentage of all TFBSs from each gene group (p53, 83 REs; NRF2, 21 REs; or NFκB, 21 REs) that fall within the x-axis conservation bins (red bars); data for randomly sampled fragments from human coding regions (blue bars); and gene promoters (gray bars). Coding regions (representing sequence under purifying selection) and randomly sampled promoter regions (representing sequence under more neutral selection) were sampled 1,000 trials; error bars are narrower than the line art. Averages and standard errors for the sets of known TFBSs are reported above each graph.

Figure 2

doi: https://doi.org/10.1371/journal.pgen.0030127.g002