RNAi, DRD1, and Histone Methylation Actively Target Developmentally Important Non-CG DNA Methylation in Arabidopsis
Figure 6
A Model for the Inheritance of Non-CG DNA Methylation in Arabidopsis thaliana
Background colors represent different pathways for targeting of non-CG DNA methylation. DRM2 is guided by an RNAi pathway initiated by DNA-dependent RNA polymerase IV. CMT3 is guided by histone H3 lysine 9 dimethylation (H3K9me2) that depends on KRYPTONITE/KYP. At some loci, histone H3 methylation is targeted by RNAi (represented by dotted arrow). DRD1 controls both DRM2 and CMT3, but there is also a DRD1-independent pathway that directs CMT3.