Genome-Wide Associations of Gene Expression Variation in Humans
Figure 1
QQ Plot of cis versus trans HSA20 −log10p-Values
The figure shows the contrast of −log10p-values deriving from associations of SNPs and genes within the 10-Mb region of HSA20 with −log10p-values deriving from associations between genes on the 10-Mb region HSA20 with SNPs in one of ten ENCODE regions. Note that the distribution falls off the diagonal around −log10p = 4, which we consider the borderline for the high enrichment of cis significant effects. A similar pattern is observed with any set of trans −log10p-values on HSA20 or any other cis vs. trans contrast in any region we tested.