Meneco, a Topology-Based Gap-Filling Tool Applicable to Degraded Genome-Wide Metabolic Networks
Fig 4
Applying the gap-filling procedure Meneco on three benchmarks built from E. coli networks of different quality.
For three different reference networks (iJR904, iAF1260 and iJO1366), the Meneco tool was applied to 3,600 pairs consisting of a degraded E. coli metabolic networks (40 different networks with levels of degradation indicated by the abscissa) and a random biomass reaction (90 different targets sets). The initial E. coli network was used as a reference database to perform the completion. The percentage of functional networks after completion is indicated on the ordinate axis.