The Role of Inhibition in a Computational Model of an Auditory Cortical Neuron during the Encoding of Temporal Information
Fig 6
Temporal dynamics of synchronized and non-synchronized neurons.
a. Net excitation (excitatory-inhibitory conductance) for a single acoustic pulse in a simulated synchronized neuron. I-E delay = 5 ms, E strength = 3 nS, I/E ratio = 1.5. b. Net excitation (excitatory-inhibitory conductance) for a single acoustic pulse in a simulated non-synchronized neuron. I-E delay = 0 ms, E strength = 0.6 nS, I/E ratio = 0.9. c. Minimum latency distribution for acoustic pulse train responses in simulated neurons. Mean: sync = 10.8 ms, nonsync = 16.6 ms, Wilcoxon rank sum test: P < 1.4 x 10-89. d. Minimum latency distribution for acoustic pulse train responses in real neurons. Mean: sync = 18.1 ms, nonsync = 51.1 ms, Wilcoxon rank sum test: P<4.6 x 10-9. e. Onset/sustained ratio distribution for pure tone responses in simulated neurons. Mean: sync = 0.69, nonsync = 0.18, Wilcoxon rank sum test: P < 6.1 x 10-124. f. Onset/sustained ratio distribution for pure tone responses in real neurons. Mean: sync = 0.60, nonsync = 0.25, Wilcoxon rank sum test: P<2.3 x 10-9.