Modulation of Calmodulin Lobes by Different Targets: An Allosteric Model with Hemiconcerted Conformational Transitions
Figure 3
Sequence of the four calcium-binding pockets (EF-loops) of calmodulin.
The calcium ion coordinates with the first, third, fifth, seventh and twelft residue of the loop, and also with the ninth through a coordinating water molecule (W). Highly conserved residues are in dark gray.