Computer Simulations Suggest a Key Role of Membranous Nanodomains in Biliary Lipid Secretion
Figure 4
Influence of membrane lipid composition on lipid extraction.
Simulated lipid extraction at varying CH and PC content of the exoplasmic leaflet of the apical membrane. Simulations refer to a life-time of 1 ms. Shown are the EMF (black curves) and the LSR (grey curves, logarithmic scale) as a function of CH content (A) or PC content (B) in the membrane for the extraction of single lipids and patches of 19, 169 and 631 lipids. The mean lipid composition of the soluble Ld nanodomains is depicted as blue (CH), green (PC) and red (SM) areas. (A) The CH content of the outer leaflet was varied from 0–70% at constant PC:SM ratio of 3:1. (B) The PC content of the outer leaflet was varied from 0–100% at a CH:SM ratio of 7:3.