Epidemic Spreading Model to Characterize Misfolded Proteins Propagation in Aging and Associated Neurodegenerative Disorders
Figure 5
Multi-factorial impact of APOE e4 genotype on Aß propagation/deposition.
A) Explained variance of the propagation model parameters by the different APOE e4 genotypes (zero, one or two e4 allele copies). Mean (± standard error) Aß production rate (B), Aß clearance rate (C), noise standard deviation (D) and onset age of Aß propagation (E) for the different number of e4 allele copies (adjusted for gender and educational level). *p<0.05, **p<0.01, ***p<10−10, Student's t-test.