Linking Macroscopic with Microscopic Neuroanatomy Using Synthetic Neuronal Populations
Figure 1
Parametric volume representing the dentate gyrus structure.
(A) The outer boundary for the granule cell layer was created by cutting a piece out of an elliptical torus (left) into a partial structure (middle left), then adding a deflection in the z direction (middle right), and finally creating unequal septal and temporal ends (right). See Methods for details. (B) Comparison between the experimental reconstruction and model structure. The rostrocaudal, dorsoventral, and mediolateral axes are shown. Red lines depict slice angles for (C). (C) 100 µm transverse slices of septal and temporal regions at the level of the red lines in (B). Subdivisions into the different layers is indicated by colors: GCL – granule cell layer (blue), IML – inner molecular layer (green), MML – middle molecular layer (magenta), OML – outer molecular layer (red). Suprapyramidal and infrapyramidal regions are indicated. In (A) and (B), directional arrows represent 1 mm.